EEPRU Reports

Biz AN, Hernández Alava M, Wailoo A. EQ5D-5L adoption issues: the impact of switching from EQ5D-3L to a new value set for EQ5D-5L for model-based cost-effectiveness estimates in NICE technology appraisals. Universities of Sheffield and York. 2026. Report 079. doi: 10.15131/shef.data.31889425

Hernandez Alava M, Pudney S, Wailoo A. Bandwidth recommendations for mapping mean utilities. Universities of Sheffield and York. 2026. Report 080. doi: 10.15131/shef.data.31852345

Hernandez-Alava M, Wailoo A. EQ-5D-5L age adjustment estimates using the health survey for England. Universities of Sheffield and York. 2026. Report 081. doi: 10.15131/shef.data.31889488

Salas-Ortiz A, Claxton K, Longo F, Lomas J. Inequality considerations in the marginal productivity of public expenditure in social care: a scoping review. Universities of Sheffield and York. 2026. Report 081. doi: 10.15131/shef.data.31860577

Rashmin R, Lomas J. Are funding rule instrumental variables plausibly exogenous for estimating the health effects of English NHS expenditure? Universities of Sheffield and York. 2025. Report 078. doi: 10.15131/shef.data.30724211

Lomas J, Longo F, Salas-Ortiz A, Claxton K. Estimating the health benefits of increasing and reallocating expenditure on the National Health Service in England. Universities of Sheffield and York. 2025. Report 077. doi: 10.15131/shef.data.30719684

Longo F, Salas-Ortiz A, Claxton K, Lomas J. What is the impact of fiscal devolution on adult social care in England? Evidence from a quasi-natural experiment. Universities of Sheffield and York. 2025. Report 076. doi: 10.15131/shef.data.29948849

Keetharuth AD, Mukuria C, Wailoo A. EQ Health and Wellbeing (EQ-HWB): A psychometric assessment. Universities of Sheffield and York. 2025. Report 075. doi: 10.15131/shef.data.28904645

Woods B, Roque CJ, Rothery C, Sculpher M, Claxton K. Estimating the overall population health effects of uniform pricing, indication-based pricing, and alternative commercial arrangements for new pharmaceuticals in the UK NHS. Universities of Sheffield and York. 2024. Report 074. doi: 10.15131/shef.data.25406854.v1

Keetharuth A, Mukuria C, Rowen D, et al. Techniques for eliciting societal preferences for “severity” for use in health technology assessments. Universities of Sheffield and York. 2024. Report 073. doi: 10.15131/shef.data.25406713

Hill H, Brentnall AR, Duffy S, Roadevin C. Evaluation of risk stratified breast cancer screening regimens that employ artificial intelligence driven short-term risk assessment. Universities of Sheffield and York. 2024. Report 072. doi: 10.15131/shef.data.25219358

Gibbs NK, Griffin S, Gutacker N, Villasenor-Lopez A, Walker S. Elective surgery waiting time prioritisation to improve population health gains and reduce health inequalities. Universities of Sheffield and York. 2024. Report 071. doi: 10.15131/shef.data.25219343

Gibbs NK, Griffin S, Gutacker N, Villasenor-Lopez A, Walker S. A general modelling framework to estimate the impact of waiting times on health for patients undergoing elective procedures in the NHS in England. Universities of Sheffield and York. 2023. Report 070. doi: 10.15131/shef.data.25219328

Hernandez Alava M, Pudney S, Wailoo A. Ethnicity, socio-economic status and health. Universities of Sheffield and York. 2023. Report 069. doi: 10.15131/shef.data.25219322

Woods B, Schmitt L, Jankovic D, et al. Final report for the technology evaluation of cefiderocol for treating severe aerobic Gram-negative bacterial infections. Universities of Sheffield and York. 2022. Report 068. doi: 10.15131/shef.data.25219307

Harnan S, Kearns B, Scope A, et al. Final report for the technology evaluation of ceftazidime with avibactam for treating severe aerobic Gram-negative bacterial infections. Universities of Sheffield and York. 2022. Report 067. doi: 10.15131/shef.data.25219274

Hill H, Kearns B, Duffy S, et al. Estimating the cost-effectiveness of risk stratified breast cancer screening in the UK. Universities of Sheffield and York. 2022. Report 066. doi: 10.15131/shef.data.25219262

Woods B, Lomas J, Sculpher M, Weatherly H, Claxton K. Achieving dynamic efficiency in pharmaceutical innovation: identifying the optimal share of value, the payments required and evaluating pricing policies. Universities of Sheffield and York. 2022. Report 065. doi: 10.15131/shef.data.25219241

SUMMARY of Report 065 - Woods B, Lomas J, Sculpher M, Weatherly H, Claxton K, (2022) Achieving dynamic efficiency in pharmaceutical innovation: identifying the optimal share of value, the payments required and evaluating pricing policies.

Hill H, Rowen D, Keetharuth D, Wailoo A. A literature review of methods to Measure and value benefits in cost-effectiveness analyses of interventions for patients with either a short life expectancy or receiving palliative care. Universities of Sheffield and York. 2022. Report 064. doi: 10.15131/shef.data.25219178

Hernández Alava M, Pudney S, Wailoo A. Estimating the relationship between EQ-5D-5L and EQ-5D-3L: results from an English population study. Universities of Sheffield and York. 2020. Report 063. doi: 10.15131/shef.data.25219157

Faria R, Martyn-St James M, Wong R, Scope A, Sculpher M. Evidence for the impact of interventions for, and medicines reconciliation in, problematic polypharmacy: a rapid review of systematic reviews and scoping searches. Universities of Sheffield and York. 2019. Report 062. doi: 10.15131/shef.data.25219142

Lomas J, Martin S, Claxton K. Estimating the marginal productivity of the English National Health Service from 2003–04 to 2012–13. Universities of Sheffield and York. 2018. Report 061. doi: 10.15131/shef.data.25219118

Hernández-Alava M, Pudney S, Wailoo A. Quality review of a proposed EQ-5D-5L value set for England. Universities of Sheffield and York. 2018. Report 060. doi: 10.15131/shef.data.25219103

Rothery C, Woods B, Schmitt L, Claxton K, Palmer S, Sculpher M. Framework for value assessment of new antimicrobials. Implications of alternative funding arrangements for NICE Appraisal. Universities of Sheffield and York. 2018. Report 059. doi: 10.15131/shef.data.25219094

Soares M, Sculpher M, Claxton K. Health opportunity costs: assessing the implications of uncertainty using elicitation methods with experts. Universities of Sheffield and York. 2018. Report 058. doi: 10.15131/shef.data.25218998

Elliott R, Camacho E, Campbell F, et al. Prevalence and economic burden of medication errors in the NHS in England. Universities of Sheffield and York. 2018. Report 057. doi: 10.15131/shef.data.25218950

Hinde S, Griffin S. ACE: Economic evaluation of the proactive lung cluster. Universities of Sheffield and York. 2018. doi: 10.15131/shef.data.25218944

Keetharuth A, Galvan C, Ara R. Excess treatment costs (ETC) estimating the magnitude and distribution of ETC in England to inform policy formulation. Universities of Sheffield and York. 2017. doi: 10.15131/shef.data.25218926

Keetharuth A, Brazier J, Connell J, et al. Development and validation of the Recovering Quality of Life (ReQoL) outcome measure. Universities of Sheffield and York. 2017. Report 050. doi: 10.15131/shef.data.25218911

Walker S, Gutacker N, Sculpher M. A scoping review on the production of different aspects of quality of health care. Universities of Sheffield and York. 2017. Report 053. doi: 10.15131/shef.data.25218917

Mukuria C, Peasgood T, Rowen D, Brazier J. An empirical comparison of wellbeing measures used in the UK. Universities of Sheffield and York. 2016. Report 048. doi: 10.15131/shef.data.25218884

Faria R, Woods B, Griffin S, et al. Economic analysis to support NHS implementation of hepatitis C drugs. Prioritisation of the treatment options for patients chronic hepatitis C at the METAVIR F3 stage. Universities of Sheffield and York. 2015. Report 045. doi: 10.15131/shef.data.25118729

Roberts G. Estimating the “wider societal impacts” of health conditions and treatments. Universities of Sheffield and York. 2015. Report 040. doi: 10.15131/shef.data.25118687

Stevens K, Brazier J, Rowen D. Estimating an exchange rate between the EQ-5D-3L and ASCOT. Universities of Sheffield and York. 2015. Report 041. doi: 10.15131/shef.data.25118696

Ara R, Brazier J, Sculpher M, et al. A framework for conducting economic evaluations when using patient decision aids in health care decision making. Universities of Sheffield and York. 2015. Report 049. doi: 10.15131/shef.data.25218902

Faria R, Barbieri M, Griffin S, et al. Economic analyses to support NHS implementation of hepatitis C drugs: scoping study. Universities of Sheffield and York. 2015. Report 046. doi: 10.15131/shef.data.25218866

Spackman E, Hinde S, Bojke L, Payne K, Sculpher M. Cost-effective analysis of genomic tests: what are the methods challenges? Universities of Sheffield and York. 2015. Report 028. doi: 10.15131/shef.data.25118534

Keetharuth A, Mulhern B, Wong R, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audit Work package 2. How should PROMS data be collected? Universities of Sheffield and York. 2015. Report 039. doi: 10.15131/shef.data.25118678

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix K – Cardiovascular. Universities of Sheffield and York. 2015. Report 038. doi: 10.15131/shef.data.25118675

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix J – Dementia. Universities of Sheffield and York. 2015. Report 037. doi: 10.15131/shef.data.25118669

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix I – Schizophrenia. Universities of Sheffield and York. 2015. Report 036. doi: 10.15131/shef.data.25118660

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix H – Psychological therapies. Universities of Sheffield and York. 2015. Report 035. doi: 10.15131/shef.data.25118648

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix G – Head and neck cancer. Universities of Sheffield and York. 2015. Report 034. doi: 10.15131/shef.data.25118576

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix F – Bowel cancer. Universities of Sheffield and York. 2015. Report 033. doi: 10.15131/shef.data.25118573

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix E – Diabetes. Universities of Sheffield and York. 2015. Report 032. doi: 10.15131/shef.data.25118570

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix D – Epilepsy. Universities of Sheffield and York. 2015. Report 031. doi: 10.15131/shef.data.25118558

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Appendix C – Irritable bowel disease. Universities of Sheffield and York. 2015. Report 030. doi: 10.15131/shef.data.25118552

Ara R, Duarte A, Harnan S, et al. Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work package 1. Universities of Sheffield and York. 2015. Report 029. doi: 10.15131/shef.data.25118546

Mukuria C, Rowen D, Peasgood T, Brazier J. Appendix 2 – Measures used in empirical comparison of well-being measures used in UK general population surveys. Universities of Sheffield and York. 2014. Report 027. doi: 10.15131/shef.data.25118519

Peasgood T, Brazier J, Mukuria C, Rowen D. A conceptual comparison of well-being measures used in the UK. Universities of Sheffield and York. 2014. Report 026. doi: 10.15131/shef.data.25118510

Kearns B, Rafia R, Leaviss J, et al. Whole pathway modelling of depression in patients. Theme 2: Mental Health. Part 1: Executive summary, introduction, clinical reviews and conceptual modelling. Universities of Sheffield and York. 2014. Report 042. doi: 10.15131/shef.data.25118708

Faria R, Walker S, Whyte S, et al. Getting cost-effective technologies into practice: the value of implementation. An application to novel anticoagulants in the prevention of stroke and systemic embolism. Universities of Sheffield and York. 2014. Report 022. doi: 10.15131/shef.data.25013228

Barbieri M, Richardson G, Paisley S, Sculpher M. Rapid review of existing literature on the cost-effectiveness of follow-up strategies after cancer treatment. Universities of Sheffield and York. 2014. Report 021. doi: 10.15131/shef.data.25013225

Barbieri M, Richardson G, Paisley S, Sculpher M. Rapid review of existing literature on the cost-effectiveness of alternative systems for diagnosis and referral of any cancer in primary care. Universities of Sheffield and York. 2014. Report 020. doi: 10.15131/shef.data.25013213

Whyte S, Dixon S, Faria R, et al. Getting cost-effective technologies into practice: the value of implementation. An application to B-type natriuretic peptide (BNP) testing in diagnosing chronic heart failure. Universities of Sheffield and York. 2014. Report 025. doi: 10.15131/shef.data.25013324

Walker S, Faria R, Whyte S, et al. Getting cost-effective technologies into practice: the value of implementation. Report on framework for valuing implementation initiatives. Universities of Sheffield and York. 2014. Report 024. doi: 10.15131/shef.data.25013270

Kearns B, Rafia R, Leaviss J, et al. Whole pathway modelling of depression in patients. Theme 2: Mental Health. Appendices. Universities of Sheffield and York. 2014. Report 044. doi: 10.15131/shef.data.25118723

Kearns B, Rafia R, Leaviss J, et al. Whole pathway modelling of depression in patients. Theme 2: Mental Health. Part 2: Independent economic evaluation: methods and results, discussion and conclusion. Universities of Sheffield and York. 2014. Report 043. doi: 10.15131/shef.data.25118714

Rowen D, Brazier J, Mukuria C, et al. Update: Eliciting societal preferences for weighting QALY’s according to burden of illness, size of gain and end of life. Universities of Sheffield and York. 2014. Report 018. doi: 10.15131/shef.data.25013030

Sculpher M, Walker S, Hinde S, Claxton K. Research to inform resource allocation in health and social care. Universities of Sheffield and York. 2014. Report 017. doi: 10.15131/shef.data.25012979

Faria R, Barbieri M, Light, K, Sculpher M. Economics of medicines optimisation. Universities of Sheffield and York. 2014. Report 016. doi: 10.15131/shef.data.25012931

Walker S, Dixon S, Palmer S, Sculpher M. Getting cost-effectiveness technologies into practice: the value of implementation. Universities of Sheffield and York. 2013. Report 014. doi: 10.15131/shef.data.25012835

Tappenden P, Bessey A, McKenna C, Sculpher M. The likely impact of earlier diagnosis of cancer on costs and benefits to the NHS. Universities of Sheffield and York. 2013. Report 015. doi: 10.15131/shef.data.25012877

Rowen D, Dixon S, Hernandez M, Mukuria C. Estimating informal care effects associated with EQ-5D tariff values for use in economic evaluation. Universities of Sheffield and York. 2013. Report 012. doi: 10.15131/shef.data.25012766

Mukuria C, Rowen D, Hernandez M, Dixon S. Examining productivity losses associated with health related quality of life using patient data. Universities of Sheffield and York. 2013. Report 013. doi: 10.15131/shef.data.25012832

Ara R, Kearns B, Mukuria C, van Hout B, Brazier J. Examining productivity losses associated with health related quality of life using patient and general population data. Universities of Sheffield and York. 2013. Report 008. doi: 10.15131/shef.data.25012661

Brazier J, Rowen D, Murkuria C, et al. Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing: a report of the main survey. Universities of Sheffield and York. 2013. Report 011. doi: 10.15131/shef.data.24534376

Ara R, Barbieri M, Weatherly H, et al. A rapid review of the cost-effectiveness of interventions across the cancer patient pathways: radiotherapy and surgery. Universities of Sheffield and York. 2013. Report 006. doi: 10.15131/shef.data.25012634

Ara R, van Hout B, Kearns B, Brazier JE. Case-mix methodology for the NHS outcomes framework GP patient survey questionnaire data. Universities of Sheffield and York. 2013. Report 007. doi: 10.15131/shef.data.25012649

Essat M, Faria R, Gomersall T, et al. Getting cost effectiveness technologies into practice: the value of implementation. Initial scoping review for phase 1. Universities of Sheffield and York. 2013. Report 005. doi: 10.15131/shef.data.25003247

Whyte S, Harnan S, Scope A, et al. Early awareness interventions for cancer: colorectal cancer. Universities of Sheffield and York. 2012. Report 004. doi: 10.15131/shef.data.25003340

Hinde S, McKenna C, Whyte S, et al. Modelling the cost-effectiveness of early awareness interventions for the early detection of lung cancer. Universities of Sheffield and York. 2012. Report 003. doi: 10.15131/shef.data.25002947