A literature review of methods used to value benefits in cost-effectiveness analyses of interventions for patients at the end of life  

Project theme: Outcomes 

Traditional approaches to economic evaluation (e.g. cost per QALY) are currently not applied when assessing palliative care interventions. However, there is still a need to consider the economic consequences of palliative care interventions to rank which interventions are preferable for introduction in end of life settings and consider whether such investment is justified in terms of resources that could be applied to improve health elsewhere in the NHS. 


Investigate which and how end of life specific measures (which have the key outcome domains missing from generic PBMs of health) and generic PBMs could be presented – jointly or at different stages of care - to capture multifaceted outcomes of palliative care interventions. Summarise this evidence in a framework that would recommend suitable approaches and outcome measures when an economic evaluation requires following a patient from early stages of a disease to end of life in palliative care, including how the outcomes might link together.

Project Team

Harry Hill, Donna Rowen, Anju Keetharuth, Allan Wailoo and Ruth Wong


Hill H, Rowen D, Keetharuth D, and Wailoo A, (2022) A literature review of methods to Measure and value benefits in cost-effectiveness analyses of interventions for patients with either a short life expectancy or receiving palliative care. Policy Research Unit in Economic Evaluation of Health and Social Care Interventions. Universities of Sheffield and York. Report 064. DOI: https://doi.org/10.15131/shef.data.25219178