Lay Summary

There is a challenge of capacity facing the NHS Breast Screening Programme, at a time when awareness of breast cancer risk, notably familial and genetic risk, is higher than ever. Partly because of potential reductions in mammogram reading capacity in the coming years, and partly because of a reasonable concern to optimise the harm-benefit balance of breast cancer screening, there is strong policy interest in stratified screening regimens, which involve less intensive surveillance for those at low risk and more intensive for those at high risk. This project is an economic evaluation of risk stratification approaches in comparison to the current NHS breast screening to investigate if risk stratification is cost-effective.